Epoxyeicosatrienoic acids, TRP channels, and intracellular Ca2+ in the vasculature: an endothelium-derived endothelium-hyperpolarizing factor?


Epoxyeicosatrienoic acids (EETs) are cytochrome P450derived metabolites of arachidonic acid that function as endothelium-derived hyperpolarizing factors (EDHFs) in many species, including humans. Strictly speaking, an EDHF is a substance derived from endothelial cells that stimulates hyperpolarization of the underlying vascular smooth muscle cells (VSMCs) to elicit vasorelaxation. Although a physiological role of EETs in vasomotor1 and nonvasomotor2 regulation of the vasculature is now increasingly recognized, the underlying signaling mechanisms and cell types involved remain incompletely understood.


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